Understanding liver metabolism and its role in liver disease
Core 1: Metabolomics
This study is looking at how the way your liver processes different substances can lead to liver diseases like liver cancer, and it hopes to find new ways to help patients by understanding these processes better.
Quick facts
| Grant type | P01 program project |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Sanford Burnham Prebys Medical Discovery Institute NIH-funded |
| Lab location | 1 site (La Jolla, United States) |
| Project ID | NIH-10935868 on NIH RePORTER |
What this research studies
This research investigates how the liver's metabolism affects the development of liver diseases, particularly hepatocellular carcinoma (HCC). It focuses on analyzing various metabolites and their roles in metabolic pathways related to glucose, fatty acids, and bile acids. By quantifying these metabolites and studying their behavior in cells and tissues, the research aims to uncover how abnormal metabolism contributes to liver disease progression. Patients may benefit from insights gained that could lead to new therapeutic strategies for HCC.
Who could benefit from this research
Good fit: Ideal candidates for this research include individuals with liver disease or those at high risk for developing hepatocellular carcinoma.
Not a fit: Patients with liver conditions unrelated to metabolic dysfunction may not receive benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to improved treatment options for patients with liver disease, particularly those at risk for hepatocellular carcinoma.
How similar studies have performed: Previous research has shown promising results in understanding liver metabolism and its implications for liver disease, indicating that this approach has potential for success.
Where this research is happening
La Jolla, United States
- Sanford Burnham Prebys Medical Discovery Institute — La Jolla, United States (Active)
Researchers
- Principal investigator: Scott, David Anderson — Sanford Burnham Prebys Medical Discovery Institute
- Study coordinator: Scott, David Anderson
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.