Understanding liver metabolism and its role in liver disease
Official title: Core 1: Metabolomics
Funded at Sanford Burnham Prebys Medical Discovery Institute · NIH-10935868 · Data updated 2026-11-12
This study is looking at how the way your liver processes different substances can lead to liver diseases like liver cancer, and it hopes to find new ways to help patients by understanding these processes better.
Quick facts
| Grant type | P01 program project |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Sanford Burnham Prebys Medical Discovery Institute NIH-funded |
| Lab location | 1 site (La Jolla, United States) |
| Project start | September 9, 2024 |
| Project end | August 31, 2029 |
| Funding year | 2024 |
| Award (this year) | $161,850 |
| NIH project number | 1P01CA281819-01A1 |
| Project ID | NIH-10935868 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research include individuals with liver disease or those at high risk for developing hepatocellular carcinoma.
✕Less likely to help
Patients with liver conditions unrelated to metabolic dysfunction may not receive benefit from this research.
What this research studies
This research investigates how the liver's metabolism affects the development of liver diseases, particularly hepatocellular carcinoma (HCC). It focuses on analyzing various metabolites and their roles in metabolic pathways related to glucose, fatty acids, and bile acids. By quantifying these metabolites and studying their behavior in cells and tissues, the research aims to uncover how abnormal metabolism contributes to liver disease progression. Patients may benefit from insights gained that could lead to new therapeutic strategies for HCC.
Why it matters
Potential benefit: If successful, this research could lead to improved treatment options for patients with liver disease, particularly those at risk for hepatocellular carcinoma.
How similar studies have gone: Previous research has shown promising results in understanding liver metabolism and its implications for liver disease, indicating that this approach has potential for success.
Where this research is happening
-
Sanford Burnham Prebys Medical Discovery Institute
La Jolla, United States Active
Researchers
- Principal investigator: Scott, David Anderson — Sanford Burnham Prebys Medical Discovery Institute
- Study coordinator: Scott, David Anderson
Related research
Other NIH-funded projects on the same topics.
-
Newborn screening: using gene and metabolite data to refine true vs false positives
A study using genetic and metabolomic data from newborn blood spots to better distinguish real metabolic disorders from false alarms.
-
IDEAL: How early-life immune development shapes vaccine responses and asthma risk
A child-focused project that looks at how the developing immune system in early life affects vaccine responses, respiratory infections, and asthma.
-
Integrative metabolomics to improve sarcoidosis diagnosis and prognosis
A research project from UCLA aims to find blood-based biomarkers that help diagnose sarcoidosis earlier and predict how it will progress, especially in African American women.
-
Metabolomics clues to how ultra-processed foods affect risk of type 2 diabetes
A scientist-led study will look at how eating different ultra-processed foods may change diabetes risk by using a controlled feeding trial and big population data, focusing on adults.
-
Longitudinal metabolomics in infants with food allergies
A study in infants aims to understand how gut metabolites relate to the development of food allergies, including IgE-mediated and non-IgE cases.
-
Biospecimen, Metabolomics, and Pathology Core for Endometrial Cancer Research
A national, multi-institutional resource collects and analyzes tissue, blood, and metabolites from endometrial cancer patients to support multiple research projects.
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.