Understanding Liver Lymphatic Vessels
Lymphatics in the liver
This work explores how new lymphatic vessels form in the liver and their role in liver health and disease.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Yale University NIH-funded |
| Lab location | 1 site (New Haven, United States) |
| Project ID | NIH-11118977 on NIH RePORTER |
What this research studies
Our bodies have a lymphatic system that helps manage fluid and inflammation in tissues, but we don't fully understand how it works in the liver. This project aims to uncover the processes behind the growth of new lymphatic vessels in the liver and how these vessels contribute to liver conditions. We are particularly interested in how certain cells and signals, like VEGF-C, influence this process. By understanding these mechanisms, we hope to find new ways to help the liver heal and reduce inflammation.
Who could benefit from this research
Good fit: This foundational research is not directly recruiting patients but aims to benefit those with liver diseases, particularly conditions involving fibrosis and inflammation.
Not a fit: Patients without liver conditions or those whose conditions are unrelated to lymphatic system function may not directly benefit from this specific research.
Why it matters
Potential benefit: If successful, this work could lead to new treatments for liver diseases, such as fibrosis, by targeting the lymphatic system.
How similar studies have performed: Preliminary studies have shown that increasing new lymphatic vessels can reduce liver fibrosis, suggesting a promising therapeutic direction.
Where this research is happening
New Haven, United States
- Yale University — New Haven, United States (Active)
Researchers
- Principal investigator: Iwakiri, Yasuko — Yale University
- Study coordinator: Iwakiri, Yasuko
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.