Understanding liver disease through rare conditions
Liver Pathobiology: insights through the lens of rare diseases
This study is looking at chronic liver disease to find new ways to understand and treat it better, especially for people with rare liver conditions, so we can help reduce the need for liver transplants.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Yale University NIH-funded |
| Lab location | 1 site (New Haven, United States) |
| Project ID | NIH-11085227 on NIH RePORTER |
What this research studies
This research investigates chronic liver disease, which affects over a billion people worldwide and can lead to severe complications like liver fibrosis and cirrhosis. By studying individuals with rare liver conditions, the research aims to uncover new molecular mechanisms that contribute to liver pathology. The goal is to develop better diagnostic and therapeutic tools to reduce the need for liver transplants. Patients may be involved in providing genetic and clinical data to help identify these mechanisms.
Who could benefit from this research
Good fit: Ideal candidates for this research include individuals with rare liver diseases or unexplained liver dysfunction.
Not a fit: Patients with common liver diseases that are well understood and have established treatment protocols may not benefit directly from this research.
Why it matters
Potential benefit: If successful, this research could lead to improved treatments and diagnostic methods for chronic liver disease, potentially reducing the need for liver transplants.
How similar studies have performed: Previous research has shown promise in using rare disease phenotypes to uncover insights into common conditions, suggesting this approach could be beneficial.
Where this research is happening
New Haven, United States
- Yale University — New Haven, United States (Active)
Researchers
- Principal investigator: Vilarinho, Silvia — Yale University
- Study coordinator: Vilarinho, Silvia
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.