Understanding Liver Disease Progression and Gut Health in Diverse Communities
Longitudinal Study of Early NAFLD Progression and the Gut Microbiome in Asian Americans, Native Hawaiians and Whites
['FUNDING_R01'] · UNIVERSITY OF HAWAII AT MANOA · NIH-11361186
This research looks at how changes in gut bacteria might be connected to the progression of non-alcoholic fatty liver disease (NAFLD) over time in Asian Americans, Native Hawaiians, and White individuals.
Quick facts
| Phase | ['FUNDING_R01'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | UNIVERSITY OF HAWAII AT MANOA (nih funded) |
| Locations | 1 site (HONOLULU, UNITED STATES) |
| Trial ID | NIH-11361186 on ClinicalTrials.gov |
What this research studies
We are following up with participants from a previous health project to see how their liver health has changed over about 10 years. Our team will collect new information and samples to understand if specific types of gut bacteria, their metabolic activities, and certain dietary habits are linked to increases in liver fat and scarring. By comparing these factors over time, we hope to uncover important connections between gut health, diet, and the development of NAFLD. This work focuses on understanding these relationships in diverse racial and ethnic groups.
Who could benefit from this research
Good fit: This research involves participants from a previous Multiethnic Cohort Adiposity Phenotype Study, specifically Japanese American, Native Hawaiian, and White individuals aged 60-77 at their baseline assessment.
Not a fit: Patients who are not part of the specific Multiethnic Cohort Adiposity Phenotype Study or who do not have NAFLD may not directly benefit from this particular research opportunity.
Why it matters
Potential benefit: If successful, this work could help us better understand how non-alcoholic fatty liver disease progresses, potentially leading to new ways to prevent or manage this condition.
How similar studies have performed: While smaller, cross-sectional studies have linked gut bacteria to NAFLD, this project offers a novel, large-scale longitudinal approach to understand the temporal relationship.
Where this research is happening
HONOLULU, UNITED STATES
- UNIVERSITY OF HAWAII AT MANOA — HONOLULU, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: LIM, UNHEE — UNIVERSITY OF HAWAII AT MANOA
- Study coordinator: LIM, UNHEE
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.