Understanding liver disease in a family with severe conditions
Modeling and Characterization of NAFLD Phenotypes in a Severely Affected Family
This study is looking at how stem cells from a family with serious liver issues can help us learn more about non-alcoholic fatty liver disease (NAFLD) and find new ways to treat it.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of California, San Francisco NIH-funded |
| Lab location | 1 site (San Francisco, United States) |
| Project ID | NIH-11017802 on NIH RePORTER |
What this research studies
This research focuses on using patient-derived stem cells to model and understand non-alcoholic fatty liver disease (NAFLD) in a family affected by severe liver conditions. The researchers will differentiate induced pluripotent stem cells (iPSCs) into liver cells to study the disease mechanisms and identify novel genes that may contribute to NAFLD. By testing these genes, the research aims to uncover potential therapeutic targets and better understand the pathways involved in liver disease. This approach allows for a personalized investigation of the disease based on the unique genetic background of the family.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals or families with a history of non-alcoholic fatty liver disease or related liver conditions.
Not a fit: Patients without a genetic predisposition to liver disease or those with other unrelated health issues may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new insights and treatments for patients suffering from NAFLD and related liver diseases.
How similar studies have performed: Previous research has shown promise in using patient-derived stem cells to model liver diseases, indicating that this approach has potential for success.
Where this research is happening
San Francisco, United States
- University of California, San Francisco — San Francisco, United States (Active)
Researchers
- Principal investigator: Mattis, Aras Nikodemas — University of California, San Francisco
- Study coordinator: Mattis, Aras Nikodemas
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.