Understanding Liver Damage in NASH
Pathobiology of Liver Injury
This research aims to understand how liver inflammation develops in nonalcoholic steatohepatitis, or NASH, which is a common liver condition.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Mayo Clinic Rochester NIH-funded |
| Lab location | 1 site (Rochester, United States) |
| Project ID | NIH-11161443 on NIH RePORTER |
What this research studies
Our bodies' liver cells can become stressed when they have too much fat, a condition called nonalcoholic steatohepatitis (NASH). This stress causes liver cells to release tiny packages called extracellular vesicles, which can trigger inflammation. We are looking closely at how these packages interact with immune cells called macrophages that gather in the liver. By understanding these interactions, we hope to uncover the specific ways inflammation starts and gets worse in NASH.
Who could benefit from this research
Good fit: This foundational research focuses on understanding the disease mechanisms of NASH, so it is not directly recruiting patients for a clinical trial at this stage.
Not a fit: Patients without nonalcoholic steatohepatitis (NASH) would not directly benefit from this specific research.
Why it matters
Potential benefit: If successful, this work could lead to new ways to prevent or treat the liver inflammation that causes damage in NASH patients.
How similar studies have performed: This project builds upon preliminary findings from the researchers, exploring a novel mechanistic link between liver cells and immune cells in NASH.
Where this research is happening
Rochester, United States
- Mayo Clinic Rochester — Rochester, United States (Active)
Researchers
- Principal investigator: Malhi, Harmeet — Mayo Clinic Rochester
- Study coordinator: Malhi, Harmeet
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.