Understanding liver damage from burns in older adults
Aging, Burn Trauma, and Liver Damage
This study is looking into why older people tend to have more serious liver problems after getting burned, and it aims to find new ways to help them recover better by focusing on a specific protein that affects liver health.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Colorado Denver NIH-funded |
| Lab location | 1 site (Aurora, UNITED STATES) |
| Project ID | NIH-10860503 on NIH RePORTER |
What this research studies
This research investigates the reasons why older individuals experience more severe liver damage after burn injuries and aims to develop new treatment strategies to mitigate this damage. The study focuses on the role of a specific protein, MCJ, which affects liver cell metabolism following burns, particularly in aged populations. By exploring the relationship between burn injuries and liver function, the research seeks to create innovative diagnostic methods for earlier detection of liver issues in burn patients. This project is essential due to the higher mortality rates observed in older burn victims, highlighting the need for targeted interventions.
Who could benefit from this research
Good fit: Ideal candidates for this research are older adults who have experienced burn injuries and are at risk for liver damage.
Not a fit: Patients who are younger and have not sustained burn injuries may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to improved treatment options and better outcomes for older patients suffering from burn injuries.
How similar studies have performed: While the specific approach of targeting MCJ in burn-related liver damage is novel, similar studies have shown promise in understanding organ damage in older populations.
Where this research is happening
Aurora, UNITED STATES
- University of Colorado Denver — Aurora, United States (Active)
Researchers
- Principal investigator: Idrovo, Juan Pablo — University of Colorado Denver
- Study coordinator: Idrovo, Juan Pablo
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.