Understanding Liver Cell Structure in Metabolic Disease
The role of hepatic Endoplasmic Reticulum architecture in metabolic homeostasis and disease
['FUNDING_R01'] · UNIVERSITY OF CALIFORNIA BERKELEY · NIH-11175571
This research explores how the internal structure of liver cells affects metabolic health, especially in people with fatty liver disease.
Quick facts
| Phase | ['FUNDING_R01'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | UNIVERSITY OF CALIFORNIA BERKELEY (nih funded) |
| Locations | 1 site (BERKELEY, UNITED STATES) |
| Trial ID | NIH-11175571 on ClinicalTrials.gov |
What this research studies
Metabolic dysfunction-associated fatty liver disease (MAFLD) is a very common liver condition with few treatment options. Our liver cells contain a crucial part called the endoplasmic reticulum (ER), which helps process proteins and fats. We believe that changes in the ER's structure within liver cells contribute to the worsening of MAFLD. This project aims to uncover the exact ways these structural changes impact liver function and overall metabolic health, potentially leading to new ways to help patients.
Who could benefit from this research
Good fit: This foundational research is relevant for individuals living with metabolic dysfunction-associated fatty liver disease (MAFLD) or adult-onset diabetes mellitus, as it seeks to understand the underlying causes of their conditions.
Not a fit: Patients without metabolic liver conditions or related metabolic disorders would not directly benefit from this specific research.
Why it matters
Potential benefit: If successful, this research could lead to new treatments that target the structure of liver cells to improve metabolic health for patients with fatty liver disease and related conditions.
How similar studies have performed: Preliminary work from this lab has shown that restoring ER structure can improve metabolic health in obese mice, suggesting a promising new direction.
Where this research is happening
BERKELEY, UNITED STATES
- UNIVERSITY OF CALIFORNIA BERKELEY — BERKELEY, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: ARRUDA, ANA PAULA — UNIVERSITY OF CALIFORNIA BERKELEY
- Study coordinator: ARRUDA, ANA PAULA
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.
Conditions: Adult-Onset Diabetes Mellitus, Disease