Understanding Liver Cell Signals in Injury and Scarring
Deciphering Epithelial Signals in the Liver to Drive Inflammation and Fibrosis
This research aims to understand how specific signals within liver cells contribute to liver injury and scarring, hoping to find new ways to help patients with liver disease.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Yale University NIH-funded |
| Lab location | 1 site (New Haven, United States) |
| Project ID | NIH-11116959 on NIH RePORTER |
What this research studies
Our goal is to learn how certain signals, called Yap/Taz/Cyr61, affect how the liver repairs itself after both sudden and long-term damage. We want to see how these signals change other important liver cells and activate pathways that lead to scarring. By understanding these detailed interactions and decisions made by liver cells, we hope to develop new, more targeted treatments for conditions like cirrhosis.
Who could benefit from this research
Good fit: This foundational research is for future patients who experience acute or chronic liver injury, fibrosis, or cirrhosis.
Not a fit: Patients will not receive direct, immediate benefit from this basic science research, as it focuses on understanding disease mechanisms.
Why it matters
Potential benefit: If successful, this work could lead to new medical therapies that specifically target the processes causing liver scarring and its complications.
How similar studies have performed: Previous work by this team and others suggests that Yap and Taz play important roles in liver injury responses, providing a foundation for this more detailed investigation.
Where this research is happening
New Haven, United States
- Yale University — New Haven, United States (Active)
Researchers
- Principal investigator: Yimlamai, Dean — Yale University
- Study coordinator: Yimlamai, Dean
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.