Understanding liver cancer risk in patients with fatty liver disease
HCC Risk Stratification in MAFLD Cirrhosis
This study is looking at how certain health issues, like obesity and diabetes, might increase the chances of developing liver cancer in people with fatty liver disease and cirrhosis, so we can find better ways to prevent it.
Quick facts
| Grant type | P01 program project |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Baylor College of Medicine NIH-funded |
| Lab location | 1 site (Houston, United States) |
| Project ID | NIH-11159870 on NIH RePORTER |
What this research studies
This research investigates the risk factors for developing hepatocellular carcinoma (HCC) in patients with Metabolic (dysfunction) Associated Fatty Liver Disease (MAFLD) and cirrhosis. By analyzing data from a large cohort of over 5,000 cirrhosis patients, the study aims to identify metabolic markers and characteristics that contribute to HCC risk. Patients will be monitored over time to better understand how obesity, diabetes, and other metabolic disorders influence cancer development. The findings could lead to improved risk stratification tools for better prevention strategies.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals diagnosed with cirrhosis and Metabolic Associated Fatty Liver Disease (MAFLD), particularly those with metabolic disorders like obesity and diabetes.
Not a fit: Patients without cirrhosis or those who do not have metabolic disorders associated with fatty liver disease may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to better prevention and early detection strategies for liver cancer in patients with fatty liver disease.
How similar studies have performed: Previous research has shown promising results in identifying risk factors for liver cancer in similar patient populations, indicating that this approach could yield valuable insights.
Where this research is happening
Houston, United States
- Baylor College of Medicine — Houston, United States (Active)
Researchers
- Principal investigator: El-Serag, Hashem B — Baylor College of Medicine
- Study coordinator: El-Serag, Hashem B
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.