Understanding lipid transfer to improve treatments for metabolic diseases
Official title: Mapping MTP lipid transfer activities for better therapeutics
Funded at NYU Long Island School of Medicine · NIH-10805516 · Data updated 2026-11-12
This study is looking at how a protein called MTP works with fats in the body to help create certain particles that can affect your health, and the goal is to find new treatments that can lower bad cholesterol without causing unwanted side effects, which could help people dealing with heart disease and obesity.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | NYU Long Island School of Medicine NIH-funded |
| Lab location | 1 site (Mineola, United States) |
| Project start | April 1, 2021 |
| Project end | March 31, 2026 |
| Funding year | 2024 |
| Award (this year) | $598,369 |
| NIH project number | 5R01HL158054-04 |
| Project ID | NIH-10805516 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research include individuals with metabolic diseases such as apolipoprotein B deficiency or atherosclerosis.
✕Less likely to help
Patients without metabolic disorders or those who do not have issues related to lipid metabolism may not benefit from this research.
What this research studies
This research investigates how a protein called microsomal triglyceride transfer protein (MTP) interacts with different lipids that are crucial for the production of certain lipoproteins linked to metabolic diseases. By studying the structure of MTP and how it binds to various lipids, the researchers aim to develop targeted therapies that can lower harmful lipoproteins without causing side effects like liver fat accumulation. The approach includes detailed structural analysis and mutational studies to uncover the mechanisms behind lipid transfer. Patients may benefit from new treatments that effectively manage conditions like atherosclerosis and obesity.
Why it matters
Potential benefit: If successful, this research could lead to more effective therapies for managing metabolic diseases and reducing cardiovascular risks.
How similar studies have gone: Previous research has shown promise in targeting lipid transfer mechanisms, suggesting that this approach could lead to significant advancements in treatment.
Where this research is happening
-
NYU Long Island School of Medicine
Mineola, United States Active
Researchers
- Principal investigator: Hussain, M Mahmood — NYU Long Island School of Medicine
- Study coordinator: Hussain, M Mahmood
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.