Understanding lipid changes in the brain in Alzheimer's disease
Spatial dysregulation of the lipidome in Alzheimers disease human and mouse brain
This project aims to map how fats and oils, called lipids, are organized in different parts of the brain to better understand their role in Alzheimer's disease.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Weill Medical Coll of Cornell Univ NIH-funded |
| Lab location | 1 site (New York, United States) |
| Project ID | NIH-11133074 on NIH RePORTER |
What this research studies
Our brains have many different types of cells, each with its own unique fat and oil (lipid) profile, which can change in diseases like Alzheimer's. We are creating a detailed map of these lipid changes across different brain regions and cell types in both human and mouse brains. This map will help us see exactly where and how these lipids are disrupted. We believe this detailed understanding will reveal new insights into how Alzheimer's disease develops, especially concerning certain genes linked to the condition.
Who could benefit from this research
Good fit: This foundational research is not directly recruiting patients but focuses on understanding the disease mechanisms relevant to individuals with Alzheimer's disease or those at risk.
Not a fit: Patients seeking immediate new treatments or direct clinical intervention would not find direct benefit from participating in this basic science project.
Why it matters
Potential benefit: If successful, this work could provide a fundamental new understanding of Alzheimer's disease, potentially leading to new targets for treatments.
How similar studies have performed: While bulk lipid studies have shown general differences, this project's spatially-resolved approach to mapping brain lipids in Alzheimer's disease is novel.
Where this research is happening
New York, United States
- Weill Medical Coll of Cornell Univ — New York, United States (Active)
Researchers
- Principal investigator: Mcintire, Laura Beth Johnson — Weill Medical Coll of Cornell Univ
- Study coordinator: Mcintire, Laura Beth Johnson
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.