Understanding leukemia stem cells in acute myeloid leukemia
Functional Interrogation of Human Acute Myeloid Leukemia Stem Cells
Researchers will use gene-editing tools on adult AML cells to learn how leukemia stem cells start and keep the disease so future treatments can target them.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Stanford University NIH-funded |
| Lab location | 1 site (Stanford, United States) |
| Project ID | NIH-11239010 on NIH RePORTER |
What this research studies
The team will work with leukemia cells taken from adult AML patients and with lab-grown AML-like stem cells made from patient samples. They will use CRISPR/Cas9 and viral DNA-repair methods to change or correct specific mutations in those cells. Edited cells will be tested in lab models and in mice to see how those changes affect the number and behavior of leukemia stem cells and the ability to start or sustain disease. The work aims to identify which mutations control stem cell activity so scientists can develop ways to remove the cells that drive relapse.
Who could benefit from this research
Good fit: Adults with acute myeloid leukemia who can provide blood or bone marrow samples, or whose stored samples are available, are the likely candidates to contribute to this work.
Not a fit: People without AML or those seeking immediate changes to their current treatment should not expect direct clinical benefit from this project.
Why it matters
Potential benefit: If successful, this research could reveal specific targets to eliminate leukemia stem cells and lower the risk of relapse in AML patients.
How similar studies have performed: Prior lab studies have shown CRISPR editing and AML-derived iPSCs can model leukemia, but translating those findings into patient-ready therapies remains early and experimental.
Where this research is happening
Stanford, United States
- Stanford University — Stanford, United States (Active)
Researchers
- Principal investigator: Majeti, Ravindra — Stanford University
- Study coordinator: Majeti, Ravindra
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.