Understanding LATE-NC, a common cause of memory loss in older adults
Molecular and cellular underpinnings of limbic-predominant age-related TDP-43 encephalopathy neuropathological change (LATE-NC)
['FUNDING_R01'] · BRIGHAM AND WOMEN'S HOSPITAL · NIH-11135434
This research aims to uncover the basic biological changes in the brain that lead to LATE-NC, a type of dementia affecting many older people.
Quick facts
| Phase | ['FUNDING_R01'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | BRIGHAM AND WOMEN'S HOSPITAL (nih funded) |
| Locations | 1 site (BOSTON, UNITED STATES) |
| Trial ID | NIH-11135434 on ClinicalTrials.gov |
What this research studies
Many older adults experience memory loss due to a condition called LATE-NC, which is currently not well understood. This project seeks to identify the specific molecular and cellular changes that happen in the brain when LATE-NC develops. By looking closely at the genes and proteins involved, we hope to learn how this disease progresses. This foundational knowledge is crucial for creating new ways to diagnose, treat, and ultimately prevent LATE-NC in the future.
Who could benefit from this research
Good fit: This foundational research is for anyone interested in the future development of treatments for LATE-NC, a type of dementia often mistaken for Alzheimer's disease.
Not a fit: Patients seeking immediate treatment options or direct clinical intervention will not find direct benefit from this basic science project.
Why it matters
Potential benefit: If successful, this research could pave the way for new diagnostic tools and treatments for LATE-NC, offering hope to those affected by this form of dementia.
How similar studies have performed: While genetic studies have identified risk factors, the fundamental molecular and cellular causes of LATE-NC are largely unknown, making this a novel and critical area of exploration.
Where this research is happening
BOSTON, UNITED STATES
- BRIGHAM AND WOMEN'S HOSPITAL — BOSTON, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: YANG, HYUN-SIK — BRIGHAM AND WOMEN'S HOSPITAL
- Study coordinator: YANG, HYUN-SIK
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.
Conditions: Alzheimer disease dementia, Alzheimer syndrome, Alzheimer's Disease