Understanding knee osteoarthritis, pain, and movement (MOST4)
Novel Insights into Osteoarthritis, Pain and Function: MOST4
This project follows people with or at risk of knee osteoarthritis to learn how pain, function, and joint changes evolve over time.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Boston University Medical Campus NIH-funded |
| Lab location | 1 site (Boston, United States) |
| Project ID | NIH-11311312 on NIH RePORTER |
What this research studies
If you join MOST4, researchers will collect questionnaires about pain and daily function, perform physical and biomechanical tests, and take MRI images and other measurements to track joint and muscle changes. The team plans to add about 450 new participants to bring the total to roughly 2,293 people followed over time. Study activities are coordinated by cores for clinical data, imaging, and analysis, with safety oversight and input from a community advisory board. By linking exam findings, imaging, and biological markers, the study aims to find patterns that may guide more personalized care.
Who could benefit from this research
Good fit: Adults who have knee pain or are at increased risk for knee osteoarthritis (for example due to age, prior knee injury, or early joint changes) are the ideal candidates.
Not a fit: People without knee problems, children, or those seeking an experimental drug for immediate symptom relief are unlikely to receive direct benefit from this observational study.
Why it matters
Potential benefit: Findings could help tailor treatments and prevent worsening pain or loss of function for people with knee osteoarthritis.
How similar studies have performed: This is a continuation of the long-running MOST multicenter cohort, which has produced over 180 publications and established useful findings about osteoarthritis, pain, and function.
Where this research is happening
Boston, United States
- Boston University Medical Campus — Boston, United States (Active)
Researchers
- Principal investigator: Neogi, Tuhina — Boston University Medical Campus
- Study coordinator: Neogi, Tuhina
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.