Understanding knee osteoarthritis and its progression
Official title: Core B-Clinical Data Collection and Management Core
Funded at Boston University Medical Campus · NIH-11056741 · Data updated 2026-11-12
This study is looking at knee osteoarthritis to better understand how exercise can help with pain relief and how joint fluid and minerals affect the condition, and it's for anyone dealing with knee OA who wants to learn more about managing their symptoms.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Boston University Medical Campus NIH-funded |
| Lab location | 1 site (Boston, United States) |
| Project start | June 1, 2023 |
| Project end | February 29, 2028 |
| Funding year | 2025 |
| Award (this year) | $1,157,873 |
| NIH project number | 5U19AG076471-03 |
| Project ID | NIH-11056741 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are individuals with knee osteoarthritis or those at high risk of developing the condition.
✕Less likely to help
Patients with advanced knee osteoarthritis who are unlikely to participate in the study due to severe limitations may not benefit from this research.
What this research studies
This research focuses on knee osteoarthritis (OA), a debilitating condition affecting many individuals. It aims to enhance our understanding of OA through the Multicenter Osteoarthritis Study (MOST), which has been ongoing since 2003 and has enrolled thousands of participants. The current phase, MOST4, will investigate key areas such as exercise-induced pain relief, the composition of joint fluid, and mineralization within the joint. By establishing a robust infrastructure for data collection and management, the study seeks to improve the quality of data and outcomes related to OA.
Why it matters
Potential benefit: If successful, this research could lead to better understanding and potential treatments for knee osteoarthritis, improving patient quality of life.
How similar studies have gone: Previous phases of the MOST study have successfully contributed to our understanding of knee osteoarthritis, indicating a strong foundation for the current research.
Where this research is happening
-
Boston University Medical Campus
Boston, United States Active
Researchers
- Principal investigator: Cawthon, Peggy Mannen — Boston University Medical Campus
- Study coordinator: Cawthon, Peggy Mannen
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.