Understanding Kindlin Proteins in Blood and Blood Vessel Cells
Project 1- Role of Kindlins in Blood and Vascular Cell Biology
['FUNDING_P01'] · CLEVELAND CLINIC LERNER COM-CWRU · NIH-11124004
This research explores how a protein called Kindlin-2 works within the cells that make up our blood vessels and blood.
Quick facts
| Phase | ['FUNDING_P01'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | CLEVELAND CLINIC LERNER COM-CWRU (nih funded) |
| Locations | 1 site (CLEVELAND, UNITED STATES) |
| Trial ID | NIH-11124004 on ClinicalTrials.gov |
What this research studies
Our blood vessels rely on specific cells to function properly, and a protein called Kindlin-2 is very active in these cells. We want to learn more about how Kindlin-2 helps these cells work, especially its role in activating other important proteins. We are looking at whether Kindlin-2's actions are always linked to these other proteins or if it has independent functions. By studying Kindlin-2 in different blood vessel cells, we hope to understand its full impact on vascular health and disease.
Who could benefit from this research
Good fit: This foundational research is for future patients who may experience conditions related to blood vessel dysfunction, such as atherosclerosis.
Not a fit: Patients seeking immediate treatment options for existing conditions may not directly benefit from this early-stage basic science research.
Why it matters
Potential benefit: If successful, this work could lead to a deeper understanding of vascular diseases like atherosclerosis, potentially guiding the development of new treatments.
How similar studies have performed: While Kindlin-2's role in integrin activation is known, this research aims to fill significant gaps in our understanding of its broader functions in blood vessel cells.
Where this research is happening
CLEVELAND, UNITED STATES
- CLEVELAND CLINIC LERNER COM-CWRU — CLEVELAND, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: PLOW, EDWARD FRANKLIN — CLEVELAND CLINIC LERNER COM-CWRU
- Study coordinator: PLOW, EDWARD FRANKLIN
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.