Understanding Kidney Transplant Outcomes and the APOL1 Gene
8/14 APOL1 Long-term Kidney Transplantation Outcomes Network (APOLLO) Clinical Center
['FUNDING_U01'] · EMORY UNIVERSITY · NIH-11141861
This project looks at how a specific gene, APOL1, affects the long-term health of transplanted kidneys and the health of African American kidney donors.
Quick facts
| Phase | ['FUNDING_U01'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | EMORY UNIVERSITY (nih funded) |
| Locations | 1 site (ATLANTA, UNITED STATES) |
| Trial ID | NIH-11141861 on ClinicalTrials.gov |
What this research studies
We know that kidneys from African American donors sometimes don't last as long after transplant compared to other donors. This project is exploring if a gene called APOL1, which is more common in people of African ancestry, plays a role in these outcomes. We are carefully observing recipients of kidneys from African American donors and also African American living donors to understand how this gene affects both transplant success and the donor's own kidney health over time. Our goal is to gather clear information to improve kidney transplant care for everyone.
Who could benefit from this research
Good fit: This project is for individuals who have received a kidney from an African American donor or who are African American living kidney donors.
Not a fit: Patients who are not of African ancestry or who have not received a kidney from an African American donor may not directly benefit from this specific research.
Why it matters
Potential benefit: If successful, this work could lead to better ways to match kidneys for transplant and improve long-term health for both African American kidney donors and recipients.
How similar studies have performed: The APOLLO study is building upon an initial phase to definitively determine the impact of APOL1 variants on kidney transplant outcomes.
Where this research is happening
ATLANTA, UNITED STATES
- EMORY UNIVERSITY — ATLANTA, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: PASTAN, STEPHEN — EMORY UNIVERSITY
- Study coordinator: PASTAN, STEPHEN
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.