Understanding Kidney Transplant Health for African American Donors and Recipients
13/14 APOL1 Long-term Kidney Transplantation Outcomes Network (APOLLO) Clinical Center
This project looks at a specific gene in African American kidney donors and recipients to better understand how it affects transplant success and donor health.
Quick facts
| Grant type | U01 cooperative agreement |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Wake Forest University Health Sciences NIH-funded |
| Lab location | 1 site (Winston-Salem, United States) |
| Project ID | NIH-11137827 on NIH RePORTER |
What this research studies
This project is part of a larger national effort called APOLLO, which aims to improve kidney transplant outcomes. We are looking closely at specific gene variations, called APOL1 risk variants, in African American kidney donors and recipients. Our goal is to understand how these gene variations affect how long transplanted kidneys function and the long-term health of living kidney donors. By gathering this information, we hope to improve the matching process for donor kidneys and provide better guidance for both donors and recipients, ultimately leading to more successful transplants.
Who could benefit from this research
Good fit: Ideal candidates for this research would include African American individuals who are either kidney transplant recipients or living kidney donors.
Not a fit: Patients who are not of African American ancestry or who are not involved in kidney transplantation as a donor or recipient may not directly benefit from this specific research.
Why it matters
Potential benefit: If successful, this work could lead to better matching of donor kidneys, longer-lasting transplants, and improved health for African American kidney donors and recipients.
How similar studies have performed: Previous retrospective studies have suggested a link between APOL1 gene variants and kidney transplant outcomes, and this project aims to prospectively confirm and expand upon those findings.
Where this research is happening
Winston-Salem, United States
- Wake Forest University Health Sciences — Winston-Salem, United States (Active)
Researchers
- Principal investigator: Reeves-Daniel, Amber — Wake Forest University Health Sciences
- Study coordinator: Reeves-Daniel, Amber
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.