Understanding Kidney Scarring in Chronic Kidney Disease
Regulation of tubulointerstitial crosstalk by microRNAs in renal fibrosis
This work explores how tiny molecules called microRNAs help control scarring in the kidneys, which could lead to new ways to help people with chronic kidney disease.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Pittsburgh at Pittsburgh NIH-funded |
| Lab location | 1 site (Pittsburgh, United States) |
| Project ID | NIH-11089451 on NIH RePORTER |
What this research studies
Chronic kidney disease affects millions, and currently, there are no specific treatments to stop its progression, often leading to kidney failure. This research focuses on kidney scarring, known as fibrosis, which is a key problem in advancing kidney disease. We are looking at how certain small molecules, called microRNAs, influence this scarring process. By understanding these molecular signals, we hope to discover new targets for medicines that could protect the kidneys and slow down the disease.
Who could benefit from this research
Good fit: This foundational research is for individuals interested in the underlying causes of chronic kidney disease and the development of future treatments.
Not a fit: Patients seeking immediate treatment options or direct clinical intervention would not directly benefit from this early-stage laboratory research.
Why it matters
Potential benefit: If successful, this research could identify new therapeutic approaches to slow or prevent the progression of chronic kidney disease and reduce the need for dialysis or kidney transplant.
How similar studies have performed: This laboratory has previously shown that these specific microRNAs play a role in kidney development and disease in animal models, suggesting a promising direction for further investigation.
Where this research is happening
Pittsburgh, United States
- University of Pittsburgh at Pittsburgh — Pittsburgh, United States (Active)
Researchers
- Principal investigator: Ho, Jacqueline — University of Pittsburgh at Pittsburgh
- Study coordinator: Ho, Jacqueline
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.