Understanding Kidney Injury and Blood Pressure
Endothelial Epoxygenase, Kidney Injury, and Blood Pressure Regulation
This research explores how kidney damage can lead to high blood pressure and long-term kidney problems, focusing on natural protective substances in blood vessels.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Univ of Arkansas for Med Scis NIH-funded |
| Lab location | 1 site (Little Rock, United States) |
| Project ID | NIH-11090504 on NIH RePORTER |
What this research studies
When kidneys are injured, such as from a lack of blood flow or a blockage, it can cause lasting issues like high blood pressure and chronic kidney disease. This happens because the tiny blood vessels in the kidneys don't heal well, leading to problems with blood flow and inflammation. Our team is looking at special substances called EETs, which are naturally made in the body and help improve blood flow and reduce inflammation in these vessels. We believe that lower levels of EETs after kidney injury contribute to these long-term health problems. The goal is to see if increasing these EETs can protect the kidneys and prevent high blood pressure and chronic kidney disease.
Who could benefit from this research
Good fit: Patients who have experienced acute kidney injury or urinary tract obstruction and are at risk for developing hypertension and chronic kidney disease might benefit from future treatments based on this research.
Not a fit: Patients whose high blood pressure or kidney disease is not related to acute kidney injury or urinary tract obstruction may not directly benefit from this specific line of research.
Why it matters
Potential benefit: If successful, this work could lead to new ways to prevent or treat high blood pressure and chronic kidney disease that develop after kidney injury.
How similar studies have performed: While EETs are known to improve blood flow and endothelial function, their specific role in preventing salt-sensitive hypertension and chronic kidney disease after kidney injury is a novel area of focus for this project.
Where this research is happening
Little Rock, United States
- Univ of Arkansas for Med Scis — Little Rock, United States (Active)
Researchers
- Principal investigator: Imig, John D — Univ of Arkansas for Med Scis
- Study coordinator: Imig, John D
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.