Understanding kidney inflammation and scarring mechanisms
Official title: Novel mechanisms of kidney inflammation and fibrosis
Funded at University of Connecticut Sch of Med/dnt · NIH-11000758 · Data updated 2026-11-12
This study is looking at how a protein called PU.1 affects immune cells that cause inflammation and scarring in the kidneys, with the hope of finding new ways to help people with chronic kidney disease feel better.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Connecticut Sch of Med/dnt NIH-funded |
| Lab location | 1 site (Farmington, United States) |
| Project start | February 1, 2023 |
| Project end | December 31, 2026 |
| Funding year | 2025 |
| Award (this year) | $471,240 |
| NIH project number | 5R01DK134475-03 |
| Project ID | NIH-11000758 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are individuals diagnosed with chronic kidney disease who are experiencing inflammation and fibrosis in their kidneys.
✕Less likely to help
Patients with acute kidney injury or those without chronic kidney disease may not receive benefit from this research.
What this research studies
This research investigates the underlying mechanisms of kidney inflammation and fibrosis, which are common in chronic kidney disease (CKD). It focuses on the role of a specific protein called PU.1 in activating immune cells known as macrophages, which contribute to inflammation and scarring in the kidneys. By studying these processes, the research aims to identify new therapeutic strategies to treat CKD. Patients may benefit from insights that could lead to innovative treatments targeting these inflammatory pathways.
Why it matters
Potential benefit: If successful, this research could lead to new therapies that effectively reduce kidney inflammation and fibrosis, improving outcomes for patients with chronic kidney disease.
How similar studies have gone: Previous research has shown promise in targeting inflammatory pathways in chronic kidney disease, suggesting that this approach could yield significant advancements.
Where this research is happening
-
University of Connecticut Sch of Med/dnt
Farmington, United States Active
Researchers
- Principal investigator: Wang, Yanlin — University of Connecticut Sch of Med/dnt
- Study coordinator: Wang, Yanlin
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.