Understanding Kidney Health in Older Adults
Role of Estrogen Related Receptors in Age Related Kidney Disease
This work explores how certain proteins called Estrogen Related Receptors (ERRs) might protect kidney health as we get older.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Georgetown University NIH-funded |
| Lab location | 1 site (Washington, United States) |
| Project ID | NIH-11169772 on NIH RePORTER |
What this research studies
As we age, our kidneys can become less healthy, experiencing issues like poor cell function, fat buildup, and inflammation. Previous findings suggest that a healthy diet, like caloric restriction, can help prevent these changes and keep levels of important proteins called ERRs high. This project aims to understand how these ERR proteins specifically affect kidney cells and whether they can prevent or reverse age-related kidney problems by influencing fat metabolism and inflammation. We hope to learn if boosting ERR activity could be a way to keep kidneys healthier for longer.
Who could benefit from this research
Good fit: This research is relevant for adults aged 65 and older who are concerned about or experiencing age-related kidney health decline.
Not a fit: Patients without age-related kidney disease or those outside the older adult age range may not directly benefit from this specific research.
Why it matters
Potential benefit: If successful, this work could lead to new treatments that help maintain kidney function and prevent age-related kidney disease in older adults.
How similar studies have performed: Previous findings indicate that caloric restriction can prevent age-related kidney decline, and a specific treatment in mice has shown promise in reversing some kidney issues by affecting ERR proteins.
Where this research is happening
Washington, United States
- Georgetown University — Washington, United States (Active)
Researchers
- Principal investigator: Levi, Moshe — Georgetown University
- Study coordinator: Levi, Moshe
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.