Understanding kidney enzymes and blood pressure in salt-sensitive hypertension
Renal acid ceramidase-S1P pathway in salt-sensitive hypertension
This research explores how certain enzymes in the kidneys, called acid ceramidase, influence how your body handles salt and affects blood pressure, especially in people with salt-sensitive hypertension.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Virginia Commonwealth University NIH-funded |
| Lab location | 1 site (Richmond, United States) |
| Project ID | NIH-11162439 on NIH RePORTER |
What this research studies
Our bodies have special molecules called sphingolipids that act as signals in many organs, including the kidneys. One of these, S1P, is very important for how kidney cells work. We've found that S1P helps the kidneys get rid of salt, which is key for keeping blood pressure healthy. When this system doesn't work right, it can lead to high blood pressure that's sensitive to salt. This project will look closely at an enzyme called acid ceramidase, which controls how much S1P is made, to see how it impacts salt balance and blood pressure.
Who could benefit from this research
Good fit: This foundational research is relevant for individuals with salt-sensitive hypertension, as it seeks to understand the underlying biological mechanisms of their condition.
Not a fit: Patients with hypertension not related to salt sensitivity or kidney function may not directly benefit from this specific line of research.
Why it matters
Potential benefit: If successful, this work could lead to new ways to manage or treat salt-sensitive high blood pressure by targeting specific kidney enzymes.
How similar studies have performed: Previous work has shown that S1P receptors in the kidney play a role in blood pressure control, suggesting this approach builds on existing knowledge.
Where this research is happening
Richmond, United States
- Virginia Commonwealth University — Richmond, United States (Active)
Researchers
- Principal investigator: Li, Ningjun — Virginia Commonwealth University
- Study coordinator: Li, Ningjun
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.