Understanding kidney disease in type 1 diabetes through modern biopsy techniques
Pathogenesis of kidney disease in type 1 diabetes: a modern kidney biopsy cohort
This study is looking at how type 1 diabetes affects kidney health over time by examining kidney tissue from people with diabetic kidney disease, so we can better understand the condition and improve treatment options.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Washington NIH-funded |
| Lab location | 1 site (Seattle, United States) |
| Project ID | NIH-11121749 on NIH RePORTER |
What this research studies
This research aims to create a new kidney biopsy cohort to explore the molecular and metabolic characteristics of diabetic kidney disease (DKD) in individuals with type 1 diabetes (T1D). By utilizing advanced techniques like single-cell RNA sequencing, the study will analyze kidney tissue to identify key pathways involved in DKD development. The research will involve a longitudinal approach, examining patients over a critical period of 5 to 30 years of T1D. This comprehensive analysis will help in understanding how modern diabetes management affects kidney health.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals aged 21 and older who have been diagnosed with type 1 diabetes for 5 to 30 years.
Not a fit: Patients with type 1 diabetes who have not experienced any kidney-related complications may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to improved understanding and treatment options for kidney disease in patients with type 1 diabetes.
How similar studies have performed: Previous landmark studies on kidney biopsies have significantly advanced our understanding of diabetic kidney disease, suggesting that this approach has a strong potential for success.
Where this research is happening
Seattle, United States
- University of Washington — Seattle, United States (Active)
Researchers
- Principal investigator: De Boer, Ian H — University of Washington
- Study coordinator: De Boer, Ian H
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.