Understanding kidney disease in type 1 diabetes through modern biopsy techniques
Official title: Pathogenesis of kidney disease in type 1 diabetes: a modern kidney biopsy cohort
Funded at University of Washington · NIH-11121749 · Data updated 2026-11-12
This study is looking at how type 1 diabetes affects kidney health over time by examining kidney tissue from people with diabetic kidney disease, so we can better understand the condition and improve treatment options.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Washington NIH-funded |
| Lab location | 1 site (Seattle, United States) |
| Project start | May 23, 2022 |
| Project end | March 31, 2027 |
| Funding year | 2025 |
| Award (this year) | $606,603 |
| NIH project number | 5R01DK132399-04 |
| Project ID | NIH-11121749 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are individuals aged 21 and older who have been diagnosed with type 1 diabetes for 5 to 30 years.
✕Less likely to help
Patients with type 1 diabetes who have not experienced any kidney-related complications may not benefit from this research.
What this research studies
This research aims to create a new kidney biopsy cohort to explore the molecular and metabolic characteristics of diabetic kidney disease (DKD) in individuals with type 1 diabetes (T1D). By utilizing advanced techniques like single-cell RNA sequencing, the study will analyze kidney tissue to identify key pathways involved in DKD development. The research will involve a longitudinal approach, examining patients over a critical period of 5 to 30 years of T1D. This comprehensive analysis will help in understanding how modern diabetes management affects kidney health.
Why it matters
Potential benefit: If successful, this research could lead to improved understanding and treatment options for kidney disease in patients with type 1 diabetes.
How similar studies have gone: Previous landmark studies on kidney biopsies have significantly advanced our understanding of diabetic kidney disease, suggesting that this approach has a strong potential for success.
Where this research is happening
-
University of Washington
Seattle, United States Active
Researchers
- Principal investigator: De Boer, Ian H — University of Washington
- Study coordinator: De Boer, Ian H
Related research
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-
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A two-arm study in adults with type 1 diabetes tests whether high-tech glucose control plus education or targeted training can help people regain awareness of low blood sugar.
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Techniques for restoring awareness of low blood sugar in adults with type 1 diabetes
A randomized trial compares different approaches to help adults with type 1 diabetes recognize when their blood sugar is dipping so they can act quickly.
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.