Understanding kidney disease in sickle cell disorders
Molecular and Cellular Pathogenesis of Kidney Disease in Sickle Cell Disorders
This study is looking at how kidney problems can happen in people with sickle cell disorders, especially focusing on how the breakdown of red blood cells might harm the kidneys, with the goal of finding new ways to protect kidney health for these patients.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Pittsburgh at Pittsburgh NIH-funded |
| Lab location | 1 site (Pittsburgh, United States) |
| Project ID | NIH-10749914 on NIH RePORTER |
What this research studies
This research investigates how kidney diseases, such as acute kidney injury and chronic kidney disease, develop in patients with sickle cell disorders. It focuses on the role of hemolysis, where red blood cells break down, releasing harmful substances that can damage the kidneys. By studying the mechanisms behind this process, the research aims to identify potential therapeutic targets to prevent kidney injury in these patients. The approach includes analyzing the levels of specific proteins in the blood and their effects on kidney cells.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals diagnosed with sickle cell disease, particularly those who have experienced kidney-related complications.
Not a fit: Patients without sickle cell disease or those who do not have kidney complications may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new treatments that protect the kidneys of patients with sickle cell disorders.
How similar studies have performed: Previous research has shown promising results in understanding kidney complications in sickle cell disease, but this specific approach is relatively novel.
Where this research is happening
Pittsburgh, United States
- University of Pittsburgh at Pittsburgh — Pittsburgh, United States (Active)
Researchers
- Principal investigator: Ghosh, Samit — University of Pittsburgh at Pittsburgh
- Study coordinator: Ghosh, Samit
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.