Understanding Kidney Disease in Children with HIV
Role of bFGF low affinity receptors in childhood HIVAN
This research aims to better understand why some children and adolescents living with HIV develop kidney disease, even when they are receiving treatment.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Virginia NIH-funded |
| Lab location | 1 site (Charlottesville, United States) |
| Project ID | NIH-11176050 on NIH RePORTER |
What this research studies
We know that children and adolescents with HIV, especially those with certain genetic risk factors (APOL1), are more likely to develop kidney problems. Our previous work showed that a protein called FGF-2 might speed up this kidney damage by helping HIV-infected cells reach the kidneys. This project will explore how FGF-2, along with genetic factors and HIV itself, contributes to kidney disease in children. We also hope to find new ways to identify children at risk and monitor their kidney health using non-invasive tests.
Who could benefit from this research
Good fit: Ideal candidates for related future studies would be children and adolescents living with HIV, particularly those with specific genetic risk factors for kidney disease.
Not a fit: Patients who do not have HIV or HIV-related kidney disease would not directly benefit from this specific research.
Why it matters
Potential benefit: If successful, this work could lead to better ways to predict, prevent, and monitor kidney disease in children and adolescents living with HIV.
How similar studies have performed: Previous work by this team has identified key factors like FGF-2 and APOL1 risk alleles that are associated with kidney disease in children with HIV, building a foundation for this current investigation.
Where this research is happening
Charlottesville, United States
- University of Virginia — Charlottesville, United States (Active)
Researchers
- Principal investigator: Ray, Patricio E. — University of Virginia
- Study coordinator: Ray, Patricio E.
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.