Understanding Kidney Disease at a Cellular Level
Integrated spatial interrogation of cellular and molecular signatures of human kidney disease
['FUNDING_U01'] · INDIANA UNIVERSITY INDIANAPOLIS · NIH-11173696
This project aims to uncover how kidney diseases like acute and chronic kidney failure develop by looking closely at the cells and molecules within kidney tissue.
Quick facts
| Phase | ['FUNDING_U01'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | INDIANA UNIVERSITY INDIANAPOLIS (nih funded) |
| Locations | 1 site (INDIANAPOLIS, UNITED STATES) |
| Trial ID | NIH-11173696 on ClinicalTrials.gov |
What this research studies
We want to understand why some kidney diseases get worse over time. Our approach involves examining kidney biopsy samples in great detail to map out different cell types and their interactions in 3D. By doing this, we hope to find new ways to identify how kidney injury progresses and discover new targets for treatments. This work will help us see how immune cells communicate with kidney cells and how these interactions lead to changes in the kidney that are not always clear with standard tests.
Who could benefit from this research
Good fit: Patients with acute or chronic kidney disease who have undergone or may undergo kidney biopsies could potentially contribute to or benefit from this research.
Not a fit: Patients without kidney disease or those whose condition does not involve the specific cellular and molecular pathways being studied may not directly benefit from this particular research.
Why it matters
Potential benefit: If successful, this work could lead to new ways to detect kidney disease progression earlier and develop more targeted treatments for acute and chronic kidney conditions.
How similar studies have performed: While the detailed spatial analysis of kidney tissue is an advanced approach, previous research has shown the value of studying cellular and molecular pathways in understanding disease progression.
Where this research is happening
INDIANAPOLIS, UNITED STATES
- INDIANA UNIVERSITY INDIANAPOLIS — INDIANAPOLIS, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: DAGHER, PIERRE C — INDIANA UNIVERSITY INDIANAPOLIS
- Study coordinator: DAGHER, PIERRE C
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.