Understanding kidney development and disease in young mice
Research Project 2: Molecular analysis of developing post-natal mouse kidney in health and FSGS
This study looks at how kidneys grow and develop after birth in mice, aiming to understand how different factors can impact this process, which could help us learn more about kidney diseases in children, especially a condition called FSGS.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Washington University NIH-funded |
| Lab location | 1 site (Saint Louis, United States) |
| Project ID | NIH-10915733 on NIH RePORTER |
What this research studies
This research investigates the growth and maturation of the kidney after birth, focusing on how these processes can be affected by various factors. By analyzing gene expression and cellular changes in post-natal mouse kidneys, the study aims to create a detailed reference atlas that can help understand pediatric kidney diseases, particularly focal and segmental glomerulosclerosis (FSGS). The research utilizes advanced techniques like ATAC sequencing to explore the molecular landscape of developing kidneys, which may reveal insights into how early life insults can lead to chronic kidney disease later on.
Who could benefit from this research
Good fit: Ideal candidates for this research are children and adolescents who may be at risk for kidney diseases, particularly those with a history of metabolic stress or kidney injury.
Not a fit: Patients with established end-stage kidney disease or those who are not in the developmental stages of kidney growth may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to better understanding and treatment options for kidney diseases in children.
How similar studies have performed: While there have been studies on kidney development, this research aims to fill a gap in understanding post-natal kidney maturation, making it a novel approach.
Where this research is happening
Saint Louis, United States
- Washington University — Saint Louis, United States (Active)
Researchers
- Principal investigator: Rauchman, Michael I — Washington University
- Study coordinator: Rauchman, Michael I
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.