Understanding kidney cells to slow cystic kidney disease
Targeting kidney resident macrophage niche filling to slow cystic kidney disease
['FUNDING_R01'] · UNIVERSITY OF OKLAHOMA HLTH SCIENCES CTR · NIH-11137635
This work explores how certain kidney cells contribute to cystic kidney disease, aiming to find new ways to slow its progression.
Quick facts
| Phase | ['FUNDING_R01'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | UNIVERSITY OF OKLAHOMA HLTH SCIENCES CTR (nih funded) |
| Locations | 1 site (OKLAHOMA CITY, UNITED STATES) |
| Trial ID | NIH-11137635 on ClinicalTrials.gov |
What this research studies
Our bodies have special cells called macrophages that live in the kidneys and play a role in cystic kidney disease. While targeting these cells could help patients, current methods affect macrophages throughout the body, which isn't safe for long-term use. This project focuses on understanding how these kidney macrophages are replaced after temporary removal, a process called 'niche filling.' By learning more about this process, we hope to develop a way to specifically target kidney macrophages without harming other parts of the body. This could lead to a safer and more effective treatment for cystic kidney disease.
Who could benefit from this research
Good fit: This foundational research is for patients with cystic kidney disease who may benefit from future therapies developed from these findings.
Not a fit: Patients seeking immediate treatment or direct participation in a clinical trial would not directly benefit from this early-stage laboratory research.
Why it matters
Potential benefit: If successful, this research could lead to new, safer treatments that specifically target kidney cells to slow the progression of cystic kidney disease.
How similar studies have performed: While the idea of targeting kidney macrophages is promising, this specific approach of understanding and manipulating 'niche filling' for tissue-specific depletion is a novel area of investigation.
Where this research is happening
OKLAHOMA CITY, UNITED STATES
- UNIVERSITY OF OKLAHOMA HLTH SCIENCES CTR — OKLAHOMA CITY, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: ZIMMERMAN, KURT A — UNIVERSITY OF OKLAHOMA HLTH SCIENCES CTR
- Study coordinator: ZIMMERMAN, KURT A
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.