Understanding Kidney Cell Changes in Chronic Kidney Disease
Cell Cycle and Metabolism in Chronically Injured Renal Tubules
This work explores how kidney cells respond to long-term injury to help prevent chronic kidney disease from getting worse.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Washington University NIH-funded |
| Lab location | 1 site (Saint Louis, United States) |
| Project ID | NIH-11168817 on NIH RePORTER |
What this research studies
Chronic kidney disease (CKD) affects many people, often damaging the tiny tubes in the kidneys. How these tubes react to injury can determine if the kidney heals or develops scarring, which is a sign of worsening CKD. This project looks at how long-term kidney injury changes the way kidney cells grow and use energy. We want to understand how these changes affect the survival of kidney cells and the development of scarring, with the goal of finding new ways to protect the kidneys.
Who could benefit from this research
Good fit: This foundational research is for patients interested in the underlying causes of chronic kidney disease and potential future therapies.
Not a fit: Patients seeking immediate treatment options or direct clinical trial participation would not directly benefit from this basic science project.
Why it matters
Potential benefit: If successful, this work could lead to new treatments that protect kidney cells from damage and prevent the progression of chronic kidney disease.
How similar studies have performed: Preliminary data from this group suggests that slowing cell growth in kidney tubules can protect against scarring in animal models, indicating a promising new direction.
Where this research is happening
Saint Louis, United States
- Washington University — Saint Louis, United States (Active)
Researchers
- Principal investigator: Gewin, Leslie S — Washington University
- Study coordinator: Gewin, Leslie S
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.