Understanding Kidney Cell Changes in Acute and Chronic Kidney Injury
Single cell multiomic and spatial atlas of acute and chronic kidney injury
This project aims to understand the many different types of cells in the kidney and how they change when someone has acute or chronic kidney injury.
Quick facts
| Grant type | U01 cooperative agreement |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Washington University NIH-funded |
| Lab location | 1 site (Saint Louis, United States) |
| Project ID | NIH-11173787 on NIH RePORTER |
What this research studies
We are carefully examining small samples of human kidney tissue, often obtained through biopsies, to learn about the individual cells within them. By using advanced techniques, we can map out the unique characteristics of each cell and see how they are organized in the kidney. This helps us discover how healthy cells transform into damaged or diseased cells during kidney injury. Our goal is to create a detailed map of these kidney cells to better understand the disease process.
Who could benefit from this research
Good fit: This research uses kidney biopsy tissue from adult patients, 21 years or older, who have acute or chronic kidney injury.
Not a fit: Patients without kidney injury or those not undergoing kidney biopsy would not directly benefit from this specific research.
Why it matters
Potential benefit: If successful, this work could lead to a deeper understanding of kidney disease, potentially guiding the development of new ways to diagnose, treat, or prevent kidney damage.
How similar studies have performed: This project pioneers novel tissue processing methods and integrates multiple advanced technologies, building on foundational knowledge of kidney cell biology.
Where this research is happening
Saint Louis, United States
- Washington University — Saint Louis, United States (Active)
Researchers
- Principal investigator: Jain, Sanjay — Washington University
- Study coordinator: Jain, Sanjay
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.