Understanding joint degeneration and pain in the jaw
Mapping temporomandibular joint (TMJ) degeneration and pain
This study is looking at the causes of pain and damage in the jaw joint (TMJ) by examining its tiny structures in detail, which could help find new ways to treat TMJ pain for people who suffer from it.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Southern California NIH-funded |
| Lab location | 1 site (Los Angeles, UNITED STATES) |
| Project ID | NIH-11127779 on NIH RePORTER |
What this research studies
This research investigates the degeneration and pain associated with the temporomandibular joint (TMJ) by creating detailed maps of the joint's molecular and cellular structures. Using advanced imaging and single-cell technologies, the study aims to identify the underlying mechanisms of TMJ osteoarthritis (TMJOA) in mouse models that closely resemble human conditions. The findings could lead to the identification of new therapeutic targets for managing TMJ pain and degeneration.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals experiencing TMJ pain or degeneration, particularly those with osteoarthritis.
Not a fit: Patients without TMJ issues or those with other unrelated joint conditions may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to improved treatments for patients suffering from TMJ pain and degeneration.
How similar studies have performed: Previous research has shown promise in using advanced imaging techniques to understand joint degeneration, suggesting that this approach could yield valuable insights.
Where this research is happening
Los Angeles, UNITED STATES
- University of Southern California — Los Angeles, United States (Active)
Researchers
- Principal investigator: Chen, Jianfu — University of Southern California
- Study coordinator: Chen, Jianfu
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.