Understanding Iroquois Genes and Female Fertility
Iroquois function in the female reproductive tract
['FUNDING_R01'] · UNIVERSITY OF WISCONSIN-MADISON · NIH-11139403
This research explores how specific genes, called Iroquois, play a role in important aspects of female fertility, like egg supply and early pregnancy.
Quick facts
| Phase | ['FUNDING_R01'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | UNIVERSITY OF WISCONSIN-MADISON (nih funded) |
| Locations | 1 site (MADISON, UNITED STATES) |
| Trial ID | NIH-11139403 on ClinicalTrials.gov |
What this research studies
We are learning about two genes, Irx3 and Irx5, that are crucial for female fertility. These genes appear to be involved in how the ovary develops its egg supply and how an embryo successfully implants in the womb. Our work uses advanced models to understand the specific functions of these genes in different cells. We aim to discover how Irx3 affects egg health and what other genes it works with during ovary development. This knowledge could help us understand why some women experience fertility challenges.
Who could benefit from this research
Good fit: This foundational research is for anyone interested in the genetic basis of female fertility, particularly those experiencing premature ovarian insufficiency or recurrent implantation failure.
Not a fit: Patients seeking immediate clinical treatments or direct participation in a human clinical trial would not directly benefit from this basic science project.
Why it matters
Potential benefit: If successful, this research could lead to a better understanding of the genetic causes of infertility and potentially new ways to address issues with ovarian reserve and early pregnancy loss.
How similar studies have performed: While the specific roles of Irx3 and Irx5 in female fertility are a novel focus, other studies have successfully identified genetic factors influencing reproductive health.
Where this research is happening
MADISON, UNITED STATES
- UNIVERSITY OF WISCONSIN-MADISON — MADISON, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: JORGENSEN, JOAN S — UNIVERSITY OF WISCONSIN-MADISON
- Study coordinator: JORGENSEN, JOAN S
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.