Understanding Iron-Sulfur Proteins
Spectroscopy of Fe-S Cluster Proteins -- Information for Structure and Function
This project aims to learn more about how iron works in the body, which is important for many health conditions, including cancers.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Seti Institute NIH-funded |
| Lab location | 1 site (Mountain View, United States) |
| Project ID | NIH-11143887 on NIH RePORTER |
What this research studies
Our bodies rely on iron for many vital functions, from carrying oxygen to helping enzymes work correctly. This project uses advanced techniques like x-ray spectroscopy to look closely at how iron-sulfur proteins are structured and how they move. By using powerful tools like Nuclear Resonance Vibrational Spectroscopy (NRVS) and nuclear-resonant time-domain interferometry (NR-TDI), we can gain detailed insights into these proteins. This work helps us understand how these proteins sense their environment and perform their essential roles in the body.
Who could benefit from this research
Good fit: This foundational work is not directly recruiting patients, but it is relevant to anyone interested in the basic biological mechanisms underlying diseases such as cancer.
Not a fit: Patients seeking immediate treatment options would not directly benefit from this basic science project.
Why it matters
Potential benefit: A deeper understanding of how iron-sulfur proteins function could lead to new ways to address diseases like cancer by targeting these fundamental biological processes.
How similar studies have performed: This project builds upon existing spectroscopic methods, applying advanced techniques to gain novel insights into the structure and function of iron-sulfur proteins.
Where this research is happening
Mountain View, United States
- Seti Institute — Mountain View, United States (Active)
Researchers
- Principal investigator: Cramer, Stephen P. — Seti Institute
- Study coordinator: Cramer, Stephen P.
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.