Understanding iron deficiency in heart failure with preserved ejection fraction
Official title: Characterization of Functional Iron Deficiency and Repletion in Heart Failure with Preserved Ejection Fraction
Funded at Massachusetts General Hospital · NIH-10867349 · Data updated 2026-11-12
This study is looking at how low iron levels might affect people with heart failure who still have good heart function, focusing on how it impacts their ability to exercise and enjoy life, with the hope of finding better treatments to help them feel better.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Massachusetts General Hospital NIH-funded |
| Lab location | 1 site (Boston, United States) |
| Project start | August 15, 2021 |
| Project end | June 30, 2025 |
| Funding year | 2024 |
| Award (this year) | $601,100 |
| NIH project number | 5R01HL159514-04 |
| Project ID | NIH-10867349 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are adults diagnosed with heart failure and preserved ejection fraction, particularly those experiencing symptoms related to iron deficiency.
✕Less likely to help
Patients with heart failure who do not have iron deficiency or those with reduced ejection fraction may not benefit from this research.
What this research studies
This research investigates the role of functional iron deficiency in patients with heart failure who have preserved ejection fraction (HFpEF). It aims to understand how low iron levels affect exercise capacity and overall quality of life in these patients. By examining the relationship between iron levels and heart function, the study seeks to identify potential treatments that could improve patient outcomes. The research will involve blood tests to measure iron levels and assess their impact on heart health.
Why it matters
Potential benefit: If successful, this research could lead to improved treatments for heart failure patients, enhancing their exercise capacity and quality of life.
How similar studies have gone: Previous research has shown that correcting iron deficiency in heart failure patients with reduced ejection fraction can improve outcomes, suggesting potential for similar benefits in those with preserved ejection fraction.
Where this research is happening
-
Massachusetts General Hospital
Boston, United States Active
Researchers
- Principal investigator: Lewis, Gregory Dyer — Massachusetts General Hospital
- Study coordinator: Lewis, Gregory Dyer
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.