Understanding Intestinal Growth After Surgery
Intestinal Mucosal Growth in Health and Surgical Diseases
This research explores how the gut lining grows and repairs itself, especially in patients recovering from major abdominal surgeries and receiving special nutrition.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Maryland Baltimore NIH-funded |
| Lab location | 1 site (Baltimore, United States) |
| Project ID | NIH-11128766 on NIH RePORTER |
What this research studies
Many patients face challenges with their gut lining after extensive surgeries, particularly when they rely on intravenous feeding. When the gut lining doesn't renew properly, it can lead to serious infections and organ problems. We are working to understand the natural processes that help the gut lining grow and stay healthy, focusing on specific molecules called RNA-binding proteins and long noncoding RNAs. Our goal is to uncover how these molecules influence gut repair and how we might use this knowledge to help patients recover better.
Who could benefit from this research
Good fit: This foundational research is relevant for patients who have undergone extensive gastrointestinal surgeries and experience issues with gut healing or rely on total parenteral nutrition (TPN).
Not a fit: Patients without critical surgical illnesses or those not experiencing impaired intestinal mucosal growth would not directly benefit from this specific research.
Why it matters
Potential benefit: If successful, this work could lead to new ways to protect and heal the gut lining in patients after major surgery, potentially reducing complications like infections.
How similar studies have performed: Our group was among the first to identify the role of specific RNA-binding proteins and long noncoding RNAs in gut mucosal growth, making this a novel area of exploration.
Where this research is happening
Baltimore, United States
- University of Maryland Baltimore — Baltimore, United States (Active)
Researchers
- Principal investigator: Wang, Jian-Ying — University of Maryland Baltimore
- Study coordinator: Wang, Jian-Ying
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.