Understanding inner retinal changes in retinitis pigmentosa
Official title: Inner retinal dysfunction in retinitis pigmentosa
Funded at University of Illinois at Chicago · NIH-10896158 · Data updated 2026-11-12
This study is looking at how retinitis pigmentosa affects the inner part of the eye after the light-sensing cells are lost, using special tests to see how this impacts vision, and it aims to find ways to help improve sight for people with this condition.
Quick facts
| Grant type | Career grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Illinois at Chicago NIH-funded |
| Lab location | 1 site (Chicago, UNITED STATES) |
| Project start | September 30, 2022 |
| Project end | June 30, 2026 |
| Funding year | 2024 |
| Award (this year) | $246,241 |
| NIH project number | 5K08EY034211-03 |
| Project ID | NIH-10896158 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are individuals diagnosed with retinitis pigmentosa who are experiencing vision loss.
✕Less likely to help
Patients with other forms of retinal degeneration unrelated to retinitis pigmentosa may not benefit from this research.
What this research studies
This research investigates how retinitis pigmentosa (RP), a common inherited retinal disease, affects the inner retina, particularly focusing on the changes that occur after the loss of photoreceptors. By using a technique called electroretinography (ERG), the study aims to assess the dysfunction in the inner retina both in patients and animal models. The goal is to understand how these changes impact visual function and to explore potential therapeutic strategies that could help restore vision. The research combines clinical insights with animal studies to provide a comprehensive understanding of the disease.
Why it matters
Potential benefit: If successful, this research could lead to new strategies for preventing or restoring vision loss in patients with retinitis pigmentosa.
How similar studies have gone: Other research has shown promising results in understanding retinal changes in similar conditions, suggesting that this approach could yield valuable insights.
Where this research is happening
-
University of Illinois at Chicago
Chicago, United States Active
Researchers
- Principal investigator: Hyde, Robert — University of Illinois at Chicago
- Study coordinator: Hyde, Robert
Related research
Other NIH-funded projects on the same topics.
-
Inflammation in MERTK-related retinitis pigmentosa
This project aims to understand whether losing the MERTK gene causes retinal inflammation that leads to vision loss in people with MERTK-related retinitis pigmentosa.
-
Enhancing cone survival in RP through targeted cell-specific CRISPR therapy
A patient-friendly look at a new approach to protect cone cells in retinitis pigmentosa using precise gene editing to support vision.
-
Oral, once-daily MC16 medicine for retinitis pigmentosa
A gene-mutation-agnostic pill (MC16) is being studied to help people with retinitis pigmentosa by addressing a common cellular problem in the eye.
-
Role of IPM Proteoglycans in Retinal Health and Inherited Blindness
This grant studies how specific retinal extracellular matrix proteins (IMPG1 and IMPG2) affect eye health and contribute to retinitis pigmentosa, with potential implications for people who have or are at risk for inherited blindness.
-
NAC Attack: a late-stage trial for preserving vision in RP patients
A large, multi-site study is testing whether taking a daily NAC pill can help people with retinitis pigmentosa keep more of their vision.
-
Non-invasive biomarker for mitochondria health in retinitis pigmentosa
Aims to test a new, non-invasive OCT-based biomarker to explain and predict how mitochondria function affects cone cells in people with retinitis pigmentosa.
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.