Understanding injuries to the corneal endothelium from blast exposure
Injuries of the Corneal Endothelium
This study looks at how injuries to the inner layer of the eye, especially from blasts, can impact vision and eye health in veterans, and it aims to find ways to protect these important cells and improve treatments for anyone affected.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | VA Western New York Healthcare System NIH-funded |
| Lab location | 1 site (Buffalo, United States) |
| Project ID | NIH-10951506 on NIH RePORTER |
What this research studies
This research investigates how injuries to the corneal endothelium, particularly from blast exposure, affect vision and eye health. It focuses on the mechanisms of cell loss in the cornea, especially in veterans who may experience additional damage during cataract and glaucoma surgeries. By studying post-mortem human eyes, the research aims to identify the specific patterns of damage and explore potential interventions to protect these vital cells. The goal is to enhance our understanding of corneal health and improve treatment options for those affected.
Who could benefit from this research
Good fit: Ideal candidates for this research include veterans and civilians who have experienced eye injuries from blasts or are at risk of corneal endothelial cell loss due to trauma or surgery.
Not a fit: Patients without a history of eye injuries or those not at risk for corneal endothelial cell loss may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to improved strategies for preserving corneal endothelial cells and preventing vision loss in patients with blast-related injuries.
How similar studies have performed: While there is limited data on this specific topic, preliminary findings suggest that understanding cellular responses to blast exposure could lead to effective interventions, indicating a novel approach in this area.
Where this research is happening
Buffalo, United States
- VA Western New York Healthcare System — Buffalo, United States (Active)
Researchers
- Principal investigator: Patel, Sangita — VA Western New York Healthcare System
- Study coordinator: Patel, Sangita
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.