Understanding inherited risks for blood cancers called myeloproliferative neoplasms
Selective pressures from inherited variation impacting myeloproliferative neoplasm initiation
This work explores how inherited genetic differences can make some people more likely to develop certain blood cancers, called myeloproliferative neoplasms.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Boston Children's Hospital NIH-funded |
| Lab location | 1 site (Boston, United States) |
| Project ID | NIH-11114017 on NIH RePORTER |
What this research studies
We know that specific changes in our genes can lead to myeloproliferative neoplasms (MPNs), but we also see that these conditions often run in families. This project aims to uncover how inherited genetic variations create conditions that encourage MPNs to start. We will use advanced laboratory models, including mouse models, to see how certain genetic changes affect blood stem cells. We also plan to work with human blood stem cells to understand how inherited gene mutations contribute to the development of these cancers.
Who could benefit from this research
Good fit: This foundational research is not directly recruiting patients but focuses on understanding the genetic basis of myeloproliferative neoplasms, which could eventually benefit individuals with a family history of these conditions.
Not a fit: Patients currently undergoing treatment for MPNs may not directly benefit from this early-stage research, which focuses on disease initiation rather than existing disease management.
Why it matters
Potential benefit: If successful, this work could help us better understand who is at risk for MPNs and potentially lead to new ways to prevent or treat these blood cancers early.
How similar studies have performed: While previous studies have identified some inherited risk factors for MPNs, this project aims to provide a deeper mechanistic understanding of how these factors contribute to disease development.
Where this research is happening
Boston, United States
- Boston Children's Hospital — Boston, United States (Active)
Researchers
- Principal investigator: Sankaran, Vijay Ganesh — Boston Children's Hospital
- Study coordinator: Sankaran, Vijay Ganesh
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.