Understanding inherited pancreatitis
Official title: Mechanisms of Hereditary Pancreatitis
Funded at Mayo Clinic Jacksonville · NIH-11321534 · Data updated 2026-11-12
Researchers are using new mouse models that carry human gene changes to learn how inherited pancreatitis starts and why it raises cancer risk for people with PRSS1 mutations.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Mayo Clinic Jacksonville NIH-funded |
| Lab location | 1 site (Jacksonville, United States) |
| Project start | July 12, 2019 |
| Project end | February 28, 2028 |
| Funding year | 2026 |
| Award (this year) | $690,067 |
| NIH project number | 5R01DK117910-07 |
| Project ID | NIH-11321534 on NIH RePORTER |
Who could benefit from this research
✓Could help
People with a known PRSS1 mutation or a strong family history of hereditary pancreatitis would be the most relevant candidates to follow this research or join related future studies.
✕Less likely to help
People whose pancreatitis is caused by non-genetic factors or different genes may not directly benefit from findings focused on PRSS1-driven disease.
What this research studies
The team created mice that carry the human PRSS1R122H mutation and PRSS2 to mimic hereditary pancreatitis and watched how the disease starts and progresses. They compare animals with one versus two mutant copies and measure how different levels and locations of trypsinogen activity trigger acute and chronic pancreatitis. They also test how low versus high doses of a pancreas stimulant produce different types of pancreatic injury. Findings aim to reveal molecular steps that could become targets for future treatments or prevention in people with hereditary pancreatitis.
Why it matters
Potential benefit: If successful, this work could point to targets for therapies or prevention that reduce pancreatitis attacks and lower pancreatic cancer risk in people with hereditary pancreatitis.
How similar studies have gone: Earlier attempts to make animal models of hereditary pancreatitis had limited success, so this new mouse model showing spontaneous disease is relatively novel and promising.
Where this research is happening
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Mayo Clinic Jacksonville
Jacksonville, United States Active
Researchers
- Principal investigator: Ji, Baoan — Mayo Clinic Jacksonville
- Study coordinator: Ji, Baoan
Related research
Other NIH-funded projects on the same topics.
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Chronic Pancreatitis and Related Conditions Data Center Supports Multi-Center Research
A national effort to organize and share clinical data and biosamples from people with chronic pancreatitis, pancreatogenic diabetes, and pancreatic cancer to speed biomarker discovery and new treatments.
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Lymphatic roles in pancreatitis and recovery
This project looks at how the lymphatic system influences inflammation and healing in pancreatitis, using mouse models to identify new therapeutic targets.
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Diabetes after acute pancreatitis: understanding and tracking progression
A patient-focused look at how diabetes can develop after an episode of acute pancreatitis, using data from a large, ongoing study and AI insights.
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Continuation of Type 1 Diabetes in Acute Pancreatitis: UF Health and AdventHealth
A patient-facing overview of a long-term study tracking people with acute pancreatitis to understand how some develop type 1 diabetes later and what factors influence that process.
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Data Coordinating Center for Type 1 Diabetes in Acute Pancreatitis Consortium
A national effort to learn how pancreatitis-related Type 1 diabetes develops, by tracking patients and coordinating data to improve future care.
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Diabetes after acute pancreatitis: a patient-focused network study
A program at Indiana University is studying how diabetes can develop after an acute pancreatitis episode, with new findings that could help doctors tailor care for adults who had pancreatitis.
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.