Understanding Inherited Factors in Liver Cancer
Hereditary Genetics of Hepatocellular Carcinoma
['FUNDING_R37'] · MAYO CLINIC ROCHESTER · NIH-11115703
This work looks at how inherited genes might play a role in developing liver cancer and how this information could help guide treatments.
Quick facts
| Phase | ['FUNDING_R37'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | MAYO CLINIC ROCHESTER (nih funded) |
| Locations | 1 site (ROCHESTER, UNITED STATES) |
| Trial ID | NIH-11115703 on ClinicalTrials.gov |
What this research studies
Liver cancer, or Hepatocellular Carcinoma (HCC), is a serious condition, and we know that having a family history of HCC increases your risk. However, the specific inherited genetic changes that contribute to this risk are not yet fully understood. This project aims to identify these inherited genetic factors by studying genetic information from patients with HCC. We believe that certain inherited gene changes might make people more susceptible to HCC and could also point to specific treatments that would work best for them.
Who could benefit from this research
Good fit: Ideal candidates for this type of research would be individuals with Hepatocellular Carcinoma, especially those with a family history of the disease.
Not a fit: Patients without Hepatocellular Carcinoma or a family history of it may not directly benefit from this specific genetic investigation.
Why it matters
Potential benefit: If successful, this work could lead to new ways to identify individuals at higher risk for liver cancer and guide personalized treatment strategies using targeted therapies.
How similar studies have performed: A pilot analysis has already shown a surprisingly high rate of inherited genetic changes in cancer-associated genes in HCC patients, suggesting this approach holds promise.
Where this research is happening
ROCHESTER, UNITED STATES
- MAYO CLINIC ROCHESTER — ROCHESTER, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: WANGENSTEEN, KIRK J — MAYO CLINIC ROCHESTER
- Study coordinator: WANGENSTEEN, KIRK J
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.
Conditions: Breast Cancer 2 Gene, Breast Cancer Type 2 Susceptibility Gene