Understanding inflammation's role in brain injury after stroke
Inflammatory mechanisms in cerebral ischemia
['FUNDING_R01'] · NORTHERN CALIFORNIA INSTITUTE/RES/EDU · NIH-10599077
This study is looking at how inflammation impacts brain recovery after a stroke, focusing on a special receptor called TREM2, and it aims to find new treatment options that could help patients heal better.
Quick facts
| Phase | ['FUNDING_R01'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | NORTHERN CALIFORNIA INSTITUTE/RES/EDU (nih funded) |
| Locations | 1 site (SAN FRANCISCO, UNITED STATES) |
| Trial ID | NIH-10599077 on ClinicalTrials.gov |
What this research studies
This research investigates how inflammation affects brain injury following a stroke, focusing on a specific receptor called TREM2 that plays a crucial role in the immune response. By studying the behavior of microglia, the brain's immune cells, and their interaction with bone marrow-derived cells, the research aims to uncover mechanisms that could lead to new treatments. The approach includes using animal models to observe the effects of TREM2 on brain recovery and the potential benefits of bone marrow stem cell transplantation. Patients may benefit from insights gained about inflammation and recovery processes after a stroke.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals who have experienced a stroke or are at high risk for stroke-related complications.
Not a fit: Patients who have not experienced a stroke or have other unrelated neurological conditions may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new therapeutic strategies that improve recovery and outcomes for stroke patients.
How similar studies have performed: Previous studies have shown promise in using bone marrow-derived stem cells for stroke recovery, indicating that this research builds on established findings.
Where this research is happening
SAN FRANCISCO, UNITED STATES
- NORTHERN CALIFORNIA INSTITUTE/RES/EDU — SAN FRANCISCO, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: YENARI, MIDORI A — NORTHERN CALIFORNIA INSTITUTE/RES/EDU
- Study coordinator: YENARI, MIDORI A
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.