Understanding inflammation in cystic fibrosis lung disease
Official title: Mechanisms of Impaired Inflammation Resolution in Cystic Fibrosis Lung Disease
Funded at Dartmouth-Hitchcock Clinic · NIH-11142457 · Data updated 2026-11-12
This study is looking at how certain immune cells in the lungs of people with cystic fibrosis can cause ongoing inflammation and infections, and it hopes to find new ways to help improve lung health with a specific treatment.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Dartmouth-Hitchcock Clinic NIH-funded |
| Lab location | 1 site (Lebanon, United States) |
| Project start | August 1, 2024 |
| Project end | April 30, 2028 |
| Funding year | 2025 |
| Award (this year) | $517,299 |
| NIH project number | 5R01HL174700-02 |
| Project ID | NIH-11142457 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are individuals diagnosed with cystic fibrosis who experience chronic lung inflammation and infections.
✕Less likely to help
Patients without cystic fibrosis or those whose lung disease is not related to chronic inflammation may not benefit from this research.
What this research studies
This research investigates the mechanisms behind persistent inflammation in the lungs of patients with cystic fibrosis (CF), which leads to chronic infections and respiratory failure. The study focuses on the role of different types of lung macrophages and their response to treatment with CFTR modulator therapy. By examining how these immune cells interact and contribute to inflammation, the research aims to uncover potential new therapeutic targets to improve lung health in CF patients.
Why it matters
Potential benefit: If successful, this research could lead to new treatments that better manage inflammation and improve lung function in cystic fibrosis patients.
How similar studies have gone: Previous research has shown promising results in understanding inflammation in other chronic lung diseases, suggesting that this approach may yield valuable insights for cystic fibrosis as well.
Where this research is happening
-
Dartmouth-Hitchcock Clinic
Lebanon, United States Active
Researchers
- Principal investigator: Ashare, Alix — Dartmouth-Hitchcock Clinic
- Study coordinator: Ashare, Alix
Related research
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-
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-
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Gut microbiome in cystic fibrosis and colorectal cancer risk
Researchers are studying how the gut bacteria in adults with cystic fibrosis influence the development of colorectal cancer.
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.