Understanding inflammation in cystic fibrosis lung disease
Mechanisms of Impaired Inflammation Resolution in Cystic Fibrosis Lung Disease
This study is looking at how certain immune cells in the lungs of people with cystic fibrosis can cause ongoing inflammation and infections, and it hopes to find new ways to help improve lung health with a specific treatment.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Dartmouth-Hitchcock Clinic NIH-funded |
| Lab location | 1 site (Lebanon, United States) |
| Project ID | NIH-11142457 on NIH RePORTER |
What this research studies
This research investigates the mechanisms behind persistent inflammation in the lungs of patients with cystic fibrosis (CF), which leads to chronic infections and respiratory failure. The study focuses on the role of different types of lung macrophages and their response to treatment with CFTR modulator therapy. By examining how these immune cells interact and contribute to inflammation, the research aims to uncover potential new therapeutic targets to improve lung health in CF patients.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals diagnosed with cystic fibrosis who experience chronic lung inflammation and infections.
Not a fit: Patients without cystic fibrosis or those whose lung disease is not related to chronic inflammation may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new treatments that better manage inflammation and improve lung function in cystic fibrosis patients.
How similar studies have performed: Previous research has shown promising results in understanding inflammation in other chronic lung diseases, suggesting that this approach may yield valuable insights for cystic fibrosis as well.
Where this research is happening
Lebanon, United States
- Dartmouth-Hitchcock Clinic — Lebanon, United States (Active)
Researchers
- Principal investigator: Ashare, Alix — Dartmouth-Hitchcock Clinic
- Study coordinator: Ashare, Alix
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.