Understanding Inflammation in Children with Sepsis and Organ Failure
Inflammation Phenotypes in Pediatric Sepsis Induced Multiple Organ Failure Renewal
This work helps us understand why some children with severe infections develop organ failure, so we can find better ways to help them.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Pittsburgh at Pittsburgh NIH-funded |
| Lab location | 1 site (Pittsburgh, United States) |
| Project ID | NIH-11182498 on NIH RePORTER |
What this research studies
Every year, many children develop a severe infection called sepsis, which can lead to organ shutdown and be life-threatening. This project uses information and samples from children who have had sepsis to understand why some experience organ failure. Researchers are using advanced computer methods and genetic testing to identify specific patterns of inflammation and immune responses. The goal is to discover new ways to treat these children based on their individual needs.
Who could benefit from this research
Good fit: This research focuses on children aged 0-11 years old who have experienced sepsis and organ failure.
Not a fit: Patients who have not experienced sepsis or organ failure would not directly benefit from this specific research.
Why it matters
Potential benefit: If successful, this work could lead to new, personalized treatments for children with sepsis to prevent organ failure and improve their chances of survival.
How similar studies have performed: Previous work by this team has already identified specific subgroups of children with sepsis who respond to certain anti-inflammatory and anti-clotting therapies, and has linked genetic factors and latent infections to outcomes.
Where this research is happening
Pittsburgh, United States
- University of Pittsburgh at Pittsburgh — Pittsburgh, United States (Active)
Researchers
- Principal investigator: Carcillo, Joseph a — University of Pittsburgh at Pittsburgh
- Study coordinator: Carcillo, Joseph a
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.