Understanding inflammation caused by HIV in adolescents
Official title: High resolution inflammatory networks induced by HIV reservoirs in adolescents
Funded at Stanford University · NIH-10896821 · Data updated 2026-11-12
This study is looking at how long-term HIV infection can cause ongoing inflammation in teenagers who were born with the virus, especially those in Kenya who have been on treatment since they were young, using special lab models to better understand how this affects their immune system.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Stanford University NIH-funded |
| Lab location | 1 site (Stanford, United States) |
| Project start | August 1, 2024 |
| Project end | July 31, 2029 |
| Funding year | 2024 |
| Award (this year) | $815,573 |
| NIH project number | 1R01AI183381-01 |
| Project ID | NIH-10896821 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are adolescents who were perinatally infected with HIV and are currently receiving antiretroviral treatment.
✕Less likely to help
Patients who are not adolescents or who were not infected with HIV perinatally may not benefit from this research.
What this research studies
This research investigates how chronic HIV infection leads to persistent inflammation in adolescents, particularly those who were infected at birth. It focuses on a unique group of perinatally infected adolescents in Kenya who have been on antiretroviral treatment since early childhood. By using advanced 3D organoid models derived from pediatric tissues, the study aims to explore the mechanisms of HIV-induced inflammation and its effects on the developing immune system. The research employs gene editing and other techniques to manipulate these organoids and gain insights into the inflammatory pathways involved.
Why it matters
Potential benefit: If successful, this research could lead to improved treatment strategies that reduce inflammation and associated complications in adolescents living with HIV.
How similar studies have gone: Previous research has shown promising results in understanding HIV-induced inflammation, but this specific approach using pediatric-derived organoids is relatively novel.
Where this research is happening
-
Stanford University
Stanford, United States Active
Researchers
- Principal investigator: Blish, Catherine a — Stanford University
- Study coordinator: Blish, Catherine a
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.