Understanding inflammation and progression in blood cell mutations
Official title: Delineating Drivers of Inflammation and Progression in Clonal Hematopoiesis
Funded at Vanderbilt University Medical Center · NIH-10869051 · Data updated 2026-11-12
This study is looking at how changes in blood stem cells as we get older can cause inflammation and serious blood problems, and it's for anyone interested in understanding why some people have more severe issues than others, with hopes of finding new ways to treat these conditions.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Vanderbilt University Medical Center NIH-funded |
| Lab location | 1 site (Nashville, United States) |
| Project start | September 1, 2023 |
| Project end | August 31, 2025 |
| Funding year | 2023 |
| Award (this year) | $150,000 |
| NIH project number | 1R56DK138826-01A1 |
| Project ID | NIH-10869051 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are older adults who have been identified with clonal hematopoiesis but do not yet have a hematologic malignancy.
✕Less likely to help
Patients who are younger or do not have any identified mutations in their blood stem cells may not benefit from this research.
What this research studies
This research investigates how certain mutations in blood stem cells, which often occur as people age, can lead to inflammation and potentially serious blood disorders. By examining the interactions between these mutated cells and their environment in the bone marrow, the study aims to identify why some individuals experience severe complications while others do not. The researchers will use advanced techniques to analyze genetic and epigenetic factors that contribute to disease progression, with the goal of finding new treatment targets.
Why it matters
Potential benefit: If successful, this research could lead to better understanding and treatment options for patients with blood disorders related to aging and clonal hematopoiesis.
How similar studies have gone: Previous research has shown promising results in understanding the role of inflammation in blood disorders, suggesting that this approach could yield valuable insights.
Where this research is happening
-
Vanderbilt University Medical Center
Nashville, United States Active
Researchers
- Principal investigator: Ferrell, Paul B — Vanderbilt University Medical Center
- Study coordinator: Ferrell, Paul B
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.