Understanding inflammation and mental health issues after brain injuries
Chronic and Evolving Inflammation after Traumatic Brain Injury: Microglial Priming and Neuropsychiatric Complications
['FUNDING_R01'] · OHIO STATE UNIVERSITY · NIH-11071956
This study is looking at how a traumatic brain injury can cause lasting inflammation in the brain, which might lead to mental health issues later on, and it aims to find ways to help people who are dealing with these long-term effects.
Quick facts
| Phase | ['FUNDING_R01'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | OHIO STATE UNIVERSITY (nih funded) |
| Locations | 1 site (Columbus, UNITED STATES) |
| Trial ID | NIH-11071956 on ClinicalTrials.gov |
What this research studies
This research investigates how traumatic brain injury (TBI) leads to ongoing inflammation in the brain, which may contribute to neuropsychiatric problems over time. The study focuses on a process called 'microglial priming,' where certain immune cells in the brain become overly reactive after injury. By analyzing brain tissue from animal models, researchers aim to identify the stages of inflammation and how they relate to cognitive impairments and other mental health issues. This could help in developing targeted treatments for patients experiencing long-term effects after TBI.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals who have experienced a traumatic brain injury and are facing ongoing cognitive or psychiatric challenges.
Not a fit: Patients who have not suffered a traumatic brain injury or those with pre-existing neuropsychiatric conditions unrelated to TBI may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new therapies that alleviate neuropsychiatric complications in patients recovering from traumatic brain injuries.
How similar studies have performed: Previous research has shown promising results in understanding the role of inflammation in brain injuries, suggesting that this approach could yield significant insights.
Where this research is happening
Columbus, UNITED STATES
- OHIO STATE UNIVERSITY — Columbus, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: GODBOUT, JONATHAN P — OHIO STATE UNIVERSITY
- Study coordinator: GODBOUT, JONATHAN P
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.