Understanding inflammation and gland behavior in esophageal injury and healing
Official title: Inflammation And Submucosal Glands During Esophageal Injury And Repair
Funded at Case Western Reserve University · NIH-10932161 · Data updated 2026-11-12
This study is looking at how certain glands in the esophagus react to injury and inflammation in people with Barrett's esophagus, with the goal of finding new ways to prevent and treat esophageal cancer.
Quick facts
| Grant type | P01 program project |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Case Western Reserve University NIH-funded |
| Lab location | 1 site (Cleveland, United States) |
| Project start | September 20, 2023 |
| Project end | August 31, 2028 |
| Funding year | 2024 |
| Award (this year) | $601,859 |
| NIH project number | 5P01CA269019-02 |
| Project ID | NIH-10932161 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research include individuals diagnosed with Barrett's esophagus or those at high risk for esophageal adenocarcinoma.
✕Less likely to help
Patients without Barrett's esophagus or those not at risk for esophageal cancer may not benefit from this research.
What this research studies
This research investigates the mechanisms behind Barrett's esophagus, a condition that increases the risk of esophageal cancer. It focuses on the role of esophageal submucosal glands and their response to injury, particularly how inflammation and specific immune cells affect healing and the progression of Barrett's esophagus. By studying the relationship between cytokines and gland behavior, the research aims to identify potential biomarkers and therapeutic strategies for better clinical outcomes. Patients may benefit from insights that could lead to improved prevention and treatment options for esophageal cancer.
Why it matters
Potential benefit: If successful, this research could lead to better prevention and treatment strategies for patients at risk of esophageal cancer.
How similar studies have gone: Previous research has shown promise in understanding the role of inflammation in cancer progression, suggesting that this approach may yield valuable insights.
Where this research is happening
-
Case Western Reserve University
Cleveland, United States Active
Researchers
- Principal investigator: Garman, Katherine — Case Western Reserve University
- Study coordinator: Garman, Katherine
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.