Understanding inflammation and gland behavior in esophageal injury and healing
Inflammation And Submucosal Glands During Esophageal Injury And Repair
['FUNDING_P01'] · CASE WESTERN RESERVE UNIVERSITY · NIH-10932161
This study is looking at how certain glands in the esophagus react to injury and inflammation in people with Barrett's esophagus, with the goal of finding new ways to prevent and treat esophageal cancer.
Quick facts
| Phase | ['FUNDING_P01'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | CASE WESTERN RESERVE UNIVERSITY (nih funded) |
| Locations | 1 site (CLEVELAND, UNITED STATES) |
| Trial ID | NIH-10932161 on ClinicalTrials.gov |
What this research studies
This research investigates the mechanisms behind Barrett's esophagus, a condition that increases the risk of esophageal cancer. It focuses on the role of esophageal submucosal glands and their response to injury, particularly how inflammation and specific immune cells affect healing and the progression of Barrett's esophagus. By studying the relationship between cytokines and gland behavior, the research aims to identify potential biomarkers and therapeutic strategies for better clinical outcomes. Patients may benefit from insights that could lead to improved prevention and treatment options for esophageal cancer.
Who could benefit from this research
Good fit: Ideal candidates for this research include individuals diagnosed with Barrett's esophagus or those at high risk for esophageal adenocarcinoma.
Not a fit: Patients without Barrett's esophagus or those not at risk for esophageal cancer may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to better prevention and treatment strategies for patients at risk of esophageal cancer.
How similar studies have performed: Previous research has shown promise in understanding the role of inflammation in cancer progression, suggesting that this approach may yield valuable insights.
Where this research is happening
CLEVELAND, UNITED STATES
- CASE WESTERN RESERVE UNIVERSITY — CLEVELAND, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: GARMAN, KATHERINE — CASE WESTERN RESERVE UNIVERSITY
- Study coordinator: GARMAN, KATHERINE
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.