Understanding Inflammation and Brain Health in Young People with HIV and Life Challenges
Enhancing Novel Research for Inflammation and Cognitive Health among Adolescents and Young Adults Living with Perinatally Acquired HIV and Adversity (ENRICH+)
This project aims to understand how inflammation and life challenges affect brain health in adolescents and young adults who were born with HIV.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Columbia University Health Sciences NIH-funded |
| Lab location | 1 site (New York, United States) |
| Project ID | NIH-11192853 on NIH RePORTER |
What this research studies
Many young people born with HIV experience difficulties with thinking and memory, even when their virus is well-controlled. We believe that ongoing immune system issues, or inflammation, might be a key reason for these challenges. This project will explore how inflammation, combined with other life difficulties like early trauma or poverty, impacts brain health in these young individuals. Our goal is to uncover specific factors that drive these brain health issues so we can develop better ways to help.
Who could benefit from this research
Good fit: This research is focused on adolescents and young adults who acquired HIV at birth and are experiencing neurocognitive impairment.
Not a fit: Patients without perinatally acquired HIV or those not experiencing cognitive difficulties may not directly benefit from this specific research.
Why it matters
Potential benefit: If successful, this work could lead to new ways to prevent or treat thinking and memory problems in young people living with HIV, especially those facing additional life challenges.
How similar studies have performed: While immune dysfunction has been linked to cognitive issues in adults with horizontally acquired HIV, this project is novel in focusing on perinatally acquired HIV and the role of various adversities.
Where this research is happening
New York, United States
- Columbia University Health Sciences — New York, United States (Active)
Researchers
- Principal investigator: Robbins, Reuben N — Columbia University Health Sciences
- Study coordinator: Robbins, Reuben N
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.